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David L Lewis Selected Research

ARC-520

7/2017Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers.
1/2017Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses.
1/2015Targeted in vivo delivery of siRNA and an endosome-releasing agent to hepatocytes.

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David L Lewis Research Topics

Disease

6Chronic Hepatitis B
07/2017 - 05/2013
6Infections
01/2017 - 01/2002
3Hypersensitivity (Allergy)
07/2017 - 01/2002
3Hepatitis B
07/2017 - 09/2015
2Neoplasms (Cancer)
01/2020 - 01/2018
1Liver Diseases (Liver Disease)
01/2020
1AIDS-Related Complex (ARC)
01/2020
1Inflammation (Inflammations)
01/2020
1Renal Cell Carcinoma (Grawitz Tumor)
01/2018
1Hypoxia (Hypoxemia)
01/2018
1Viremia
09/2015
1Disease Progression
09/2015
1Hypertrophy
03/2007
1Dementia (Dementias)
02/2007
1Cognitive Dysfunction
02/2007

Drug/Important Bio-Agent (IBA)

3Proteins (Proteins, Gene)FDA Link
01/2020 - 05/2013
3ARC-520IBA
07/2017 - 01/2015
2Antiviral Agents (Antivirals)IBA
09/2015 - 09/2015
2Hepatitis B Surface Antigens (HBsAg)FDA Link
09/2015 - 09/2015
2Small Interfering RNA (siRNA)IBA
01/2015 - 03/2007
2EndotoxinsIBA
06/2002 - 01/2002
1PolymersIBA
01/2020
1Transcription Factors (Transcription Factor)IBA
01/2018
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2018
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2018
1Messenger RNA (mRNA)IBA
07/2017
1DNA (Deoxyribonucleic Acid)IBA
07/2017
1Histamine Antagonists (Antihistamines)IBA
07/2017
1Viral ProteinsIBA
07/2017
1Melitten (Melittin)IBA
01/2017
1CholesterolIBA
01/2017
1AcetylgalactosamineIBA
01/2017
1Peptides (Polypeptides)IBA
01/2017
1InterferonsIBA
09/2015
1Reverse Transcriptase InhibitorsIBA
09/2015
1Viral RNAIBA
05/2013
1Viral DNAIBA
05/2013
1PPAR alphaIBA
03/2007

Therapy/Procedure

4Therapeutics
01/2018 - 05/2013
3RNAi Therapeutics
01/2020 - 05/2013
1Investigational Therapies (Experimental Therapy)
09/2015
1Withholding Treatment
09/2015
1Home Nursing (Nursing, Home)
02/2007